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Pharmaceutical Products

 

Golden Gate TALEN Assembly Kit

TALEN (Transcription Activator-Like Effector Nucleases) technology is a new gene targeting technology. TALENs bind and cleave DNA in pairs, and their binding specificity is determined by customi


Genome Editing
-Gene Knock-out
-Gene Knock-in
-Gene Mutation
-Gene Tagging

Creative Animodel also offers economic cell lines, mice and rats generation ...
0 (#0) 5 2015.01.30 Golden Gate TALEN Assembly Kit
Pharmaceutical Products

 

Knockout Repository

Creative Animodel provides KO mouse models for commercial researchers worldwide with unparalleled access to fully-licensed, healthy knockout mouse models. Creative Animodel cryopreserves the lin


Creative Animodel provides KO mouse models for commercial researchers worldwide with unparalleled access to fully-licensed, healthy knockout mouse models. ...
0 (#0) 4 2015.01.30 Knockout Repository
Pharmaceutical Products

 

NHP Disease Models

Creative Animodel expertizes in developing and running non-human primate (NHP) animal models to test drug candidates and medical devices for their pharmacological effects and bi


We have mature technologies and know-how in the flowing NHP disease modeling. And we also work closely with our clients to develop customized models to meet their needs. ...
0 (#0) 3 2015.01.30 NHP Disease Models
Pharmaceutical Products

 

NHP Research Services

Creative Animodel has been performing vital non-human primate (NHP) studies for government and commercial clients for many years. We have a wealth of experience and capabilities to help clients


From the highest standard we set for our professional team and state-of-the-art facilities and technologies, we are confident that our tailored service will meet every specific need of our clients. If...
0 (#0) 5 2015.01.30 NHP Research Services
Pharmaceutical Products

 

Toxicokinetics Studies

Creative Animodel has years of experience and conducted several kinds of toxicity studies successfully and contributed towards critical decision making in drug discovery of several pharma


From the highest standard we set for our professional team and state-of-the-art facilities and technologies, we are confident that our tailored service will meet every specific need of our clients. If...
0 (#0) 4 2015.01.30 Toxicokinetics Studies
Pharmaceutical Products

 

Safety Pharmacology

Safety pharmacology is the study of the potential undesirable pharmacodynamic effects of a substance in relation to dosage within the substance's therapeutic range and above. It provides val


Creative Animodel consults with you to design animal study protocols balancing timing, cost and risk factors, ensuring appropriate data to support pre-clinical studies as well as the first human admin...
0 (#0) 5 2015.01.30 Safety Pharmacology
Pharmaceutical Products

 

Special Toxicology

Creative Animodel offers a complete range of standard special toxicology protocols designed for supporting submissions to international regulatory agencies. All studies are conducted in c


Creative Animodel consults with you to design animal study protocols balancing timing, cost and risk factors, ensuring appropriate data to support pre-clinical studies as well as the first human admin...
0 (#0) 4 2015.01.30 Special Toxicology
Pharmaceutical Products

 

General Toxicology

In the area of general toxicology, Creative Animodel offers our customers standard protocols designed to support drug approval submissions to domestic and international regulatory agencie


Our work is GLP compliant and AAALAC-accredited. Plus, we have a thorough understanding of global regulatory issues and can help ensure that you are conducting the right studies at each step of the pr...
0 (#0) 4 2015.01.30 General Toxicology
Pharmaceutical Products

 

Pharmacodynamics Services

Pharmacodynamics is the study of the relationship between the concentration of a drug and the response obtained in the study systems. It describes the pharmacological effect of analyzed drug.


Ceative Animodel will work closely with you to ensure that any custom protocols are executed to your exact specifications, and have documented success in implementing conventional protocols and adapti...
0 (#0) 4 2015.01.30 Pharmacodynamics Services
Pharmaceutical Products

 

Bioanalysis

Creative Animodel offers a range of bioanalytical services and uses state-of-the-art technology such as LC/MS for the accurate quantification of drugs in biological matrices. Our goal is


Ceative Animodel will work closely with you to ensure that any custom protocols are executed to your exact specifications, and have documented success in implementing conventional protocols and adapti...
0 (#0) 5 2015.01.30 Bioanalysis
Pharmaceutical Products

 

In Vivo PK

Translational Research (PK) will be involved in the design and execution of in vivo PK/ADME studies and the evaluation of clinical pharmacokinetic data to support the development of


In order to provide a significant enhancement in speed and efficiency it becomes highly beneficial in Creative Animodel to conduct both the in vivo PK quantification and identification of the major me...
0 (#0) 5 2015.01.30 In Vivo PK
Pharmaceutical Products

 

ADME Services

In vivo Creative Animodel offers a suite of in vivo ADME services and features an in vivo team with over 10 years of experience. We are


Creative Animodel offers an extensive portfolio of assay-based products and services including:
Pampa (Gi/Bbb)
Caco-2 (Unidirectional/Bidirectional)
Efflux Transpo
...
0 (#0) 3 2015.01.30 ADME Services
Pharmaceutical Products

 

Animal Model of Disease

Mammals are often used for scientific research due to their close biological resemblance to humans. Human cell lines or diseases can be introduced into these species for experimentation, particu


Models for other indications are also available for specific interests. Please contact us at info@Creative-Animodel.com for pricing and more information.
...
0 (#0) 4 2015.01.30 Animal Model of Disease
Pharmaceutical Products

 

CRISPR/Cas9 System for Mutagenesis and Genome Editing

The latest tool in genome editing-CRISPR/Cas9- allows for specific genome disruption and replacement in a flexible and simple system resulting in high specificity and low cell toxicity. It is an


We can offer the following services

Knockout cell lines
Conditional Knockout cell lines
Site-specific knock-in cell lines
Gene Mutation cell lines
0 (#0) 3 2015.01.30 CRISPR/Cas9 System for Mutagenesis and Genome Editing
Pharmaceutical Products

 

Custom TALENs Services

TALEs (Transcription Activator-Like Effectors) are proteins that bind to DNA in a sequence-specific way. By fusing such a TALE to a Nuclease (a "TALENs"), a highly specific DNA scissor


Creative animodel aims at making TALEN technology accessible for everybody and is always looking for new ways to meet the needs of our valued customers. For more information, please contact us!...
0 (#0) 4 2015.01.30 Custom TALENs Services
Pharmaceutical Products

 

Conditional Knockout

Creative Animodel has developed an innovative platform "RSKOT" (rapid and stable knockout technology) enabling the generation of conditional knockout mouse lines starting from the same


As a world leader in gene targeting services and custom mouse model production, Creative Animodel has over a decade of experience serving clients across six continents. Our full-service model has enab...
0 (#0) 4 2015.01.30 Conditional Knockout
Pharmaceutical Products

 

Constitutive Knockout

Creative Animodel's high-throughput conventional knockout technology enables us to identify and validate the utility of genomic targets within a living model at an extraordinary scale and sp


Our service offer is flexible. It can be provided on a component basis and adapted to customer requirements....
0 (#0) 4 2015.01.30 Constitutive Knockout
Pharmaceutical Products

 

Knockdown Services

RNA interference has become a widely used approach to perform gene knockdown experiments in cell cultures and more recently


Single-copy RNAi constructs are placed into the Rosa26 locus of ES cells by recombinase-mediated cassette exchange and transmitted through the germline of chimaeric mice. The site-specific insertion o...
0 (#0) 4 2015.01.30 Knockdown Services
Pharmaceutical Products

 

Knockin Services

Creative Animodel provides a high quality service for the generation of gene-targeted knock-in mouse models. Our team has many years of experience in vector design, ES cell targeting and mouse h


Materials and information provided and sent to Creative Animodel are kept private by the strictest security measures. Assay outcomes and experimental data are proprietary to our clients and are also k...
0 (#0) 3 2015.01.30 Knockin Services
Pharmaceutical Products

 

Ubiquitination

Ubiquitin is an about 8.5 kDa polypeptide consisting of 76 amino acids that is appended to the ε-NH2 of lysine in target proteins via the C-terminal glycine of ubiquitin. Following an in


Ubiquitin is an about 8.5 kDa polypeptide consisting of 76 amino acids that is appended to the ε-NH2 of lysine in target proteins via the C-terminal glycine of ubiquitin. Following an initial mon...
0 (#0) 5 2015.01.29 Ubiquitination
Pharmaceutical Products

 

N-acetylationN-acetylation, or the transfer of an acetyl group to nitrogen, occurs in almost all euk

N-acetylation, or the transfer of an acetyl group to nitrogen, occurs in almost all eukaryotic proteins through both irreversible and reversible mechanisms. N-terminal acetylation requires the c


N-acetylation, or the transfer of an acetyl group to nitrogen, occurs in almost all eukaryotic proteins through both irreversible and reversible mechanisms. N-terminal acetylation requires the cleavag...
0 (#0) 4 2015.01.29 N-acetylationN-acetylation, or the transfer of an acetyl group to nitrogen, occurs in almost all euk
Pharmaceutical Products

 

FAQ-Post Translational Modification

What are the concerns about mapping a phosphorylation site in my protein? You will have two major concerns: Coverage: Can the mass spectrometry technique(s) deliver


What are the concerns about mapping a phosphorylation site in my protein?

You will have two major concerns:
Coverage: Can the mass spectrometry technique(s) deliver high sequence...
0 (#0) 4 2015.01.29 FAQ-Post Translational Modification
Pharmaceutical Products

 

ES Cell Based Gene Overexpression

In addition to pronuclear microinjection, foreign DNA can be introduced into embryonic stem cells (ES cells). Creative Animodel has developed a novel ES cell-based technology that reduces the ri


Once your model is generated, Creative Animodel can breed, test, characterize and/or distribute it on your behalf, drawing on six decades of breeding and worldwide distribution experience for an effic...
0 (#0) 5 2015.01.27 ES Cell Based Gene Overexpression
Pharmaceutical Products

 

Mitiglinide calcium

Mitiglinide calcium Synonyms: 2H-ISOINDOLE-2-BUTANOIC ACID, OCTAHYDRO-GAMMA-OXO-ALPHA-(PHENYLMETHYL)-, CALCIUM SALT, DIHYDRATE, (AS,3AR,7AS)-;(aS,3aR,7aS)-Octahydro-gamma-oxo-alpha-(phen


Mitiglinide calcium
Synonyms: 2H-ISOINDOLE-2-BUTANOIC ACID, OCTAHYDRO-GAMMA-OXO-ALPHA-(PHENYLMETHYL)-, CALCIUM SALT, DIHYDRATE, (AS,3AR,7AS)-;(aS,3aR,7aS)-Octahydro-gamma-oxo-alpha-(phenylmeth...
0 (#0) 25 2015.01.23 Mitiglinide calcium
Pharmaceutical Products

 

Recombinant Human Cornulin, His-tagged

CRNN is a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats.


CRNN is a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. It contains two EF-hand Ca2+ binding domains in its N-terminus an...
0 (#0) 16 2015.01.22 Recombinant Human Cornulin, His-tagged